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They are fundamental components of all our tissues, including the skin
Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
This involves a rigorous review of studies, including those with potential biases favouring the arginine variant and weighing them against independent findings
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