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Notably, the diversification of gut microbiota resulting from metformin treatment was observed following oral administration in mice, a phenomenon not replicated with intraperitoneal injection (Broadfield et al., 2022)
Back de Levia-Hidalgo, A, de Leviva-Prez, A (Oct 2019) 'Pancreatic extracts for the treatment of diabetes (18891914): Acomatol', American Journal of Therapeutics , 27, 21-e12
They are not required to demonstrate efficacy before marketing, unlike licensed medications
Moreover, Doxorubicin and Cyclophosphamide significantly decreased prefrontal cortical CAT levels compared to the control group by 1.83 folds
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