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J Pharmacol Exp Ther 273:14971505 Gerets HHJ, Tilmant K, Gerin B et al (2012) Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins
After 26 weeks, the levels of hs-CRP and endothelin-1 decreased (27.5% and 18.75%, respectively) in the exenatide arm whereas the levels of fibrinogen, monocyte chemoattractant protein-1, leptin and endothelin-1 increased in the insulin glargine arm (13.4%, 30.2%, 47.5%, and 80%, respectively) [45]
GLP-1 receptor agonists have also been shown to cause weight loss in some individuals
Distant Future: The patents on the active ingredient for popular medications like semaglutide are not expected to expire for several years
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