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196 In the tumor environment, succinate could be produced and released by tumor cells, and via interacting with succinate receptor 1 to activate phosphoinositide-3-kinase/protein kinase B pathway and upregulate HIF-1, inducing macrophage polarization, and enhancing tumor cell metastasis
36-38 Low rates of hypoglycemia have been reported in clinical trials of SGLT-2 inhibitors, except in patients receiving therapy with background insulin or insulin secretagogues
Hausner H, Derving Karsbl J, Holst AG, et al
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