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and in glioma, lactate-driven Kla remodels the immunosuppressive landscape by upregulating CD73 (tumor cells), CD39/CCR8 (Treg cells), CD39 (macrophages), and CD73 (T cells), establishing a purinergic cascade where CD39 hydrolyzes ATP to AMP followed by CD73-mediated conversion to adenosine to create an immunosuppressive niche (71)
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