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In ferroptosis, free Fe2+ interacts with hydrogen peroxide to generate highly reactive lipid peroxides, resulting from the disruption of the balance between ferrous iron absorption, depletion and recycling (29)
Cortexin interacts with AMPA, kainate, mGluR1, and GABAA receptors, while cerebrolysins effects are primarily mediated through its neurotrophic factor constituents
Lin R, et al
Over the following decades, it became widely used in Europe and Asia
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