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The Billon 2025 paper (PMID 41421047) introduced SLU-PP-915 as an "orally active" sibling specifically because the parent SLU-PP-332 "lacks oral bioavailability." Despite that, the most common vendor formats are oral capsules and tablets products without published evidence that they produce systemic ERR agonism in humans
Unlike some supplements, it is also regulated
Ive explained the rationale for my recommendations to take vitamin B12 supplements once a week or once a day, or alternately eat sufficient daily B12-fortified foods
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