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Similarly, effects on children and adolescents are unknown, and use in these populations cannot be recommended
That data drives adjustments that prevent weight loss stalls on semaglutide and the frustrating weight gain that can happen on tirzepatide when nutrition falls apart
For those who have considered older medications like phentermine alongside semaglutide , the GLP-1 class has fundamentally changed expectations for what medication-assisted weight loss can achieve
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The effect remained after weight matching [35]
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