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In ISO-induced myocardial infarction, pretreatment with Gln maintained cardiac GSH kurtosis and antioxidant enzyme (GPX, SOD, CAT) activity at near-normal levels, thus preventing oxidative damage in the myocardium [111]
Phase 1 study of glutaminase (GLS) inhibitor CB-839 combined with either everolimus (E) or cabozantinib (Cabo) in patients (pts) with clear cell (cc) and papillary (pap) metastatic renal cell cancer (mRCC)
Common mild effects include nausea, headache, injection site discomfort, and temporary skin sensitivity
and Zabaleta, A
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