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In the activated state, FOXO3 can enter the nucleus and regulate the expression of a series of genes related to cell cycle, apoptosis, and autophagy (91)
Glutamine is a building block of proteins and plays a critical role in supporting the bodys immune system
& Sastrasinh, S
69 Thirdly, during the DPN, excess saturated fatty acids (SFAs) and hyperglycemia depolarize mitochondrial membranes and generate ROS, 70 which eventually produce mitochondrial dysfunction and Schwann cells (SCs) apoptosis
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