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Option 1: 2mL of bacteriostatic water (most popular) This is the ratio most researchers choose, and for good reason
The Cochrane concluded that orally administered vitamin B12 appeared to be as effective as the intramuscular route with respect to the short-term haematological and neurological responses observed in patients with deficiencies, but highlighted methodological limitations in both trials
In line with the UKB cohort data (ESM Table 9), vitamin B 12 deficiency was more prevalent in the AA genotype group treated with metformin vs GG (OR 2.17 [95% CI 1.80, 2.60]
This distinction is critical: absence of documented harm in a poorly studied compound is not the same as demonstrated safety
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