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The biological requirement for choosing one day and sticking to it is real, not arbitrary

Due to tirzepatide's long half-life (approximately five days) and delayed peak concentration (8-72 hours after injection), symptoms typically reflect steady-state effects rather than immediate post-injection peaks

Blue Cross said it spent $515 million on GLP-1s in 2025, up from $140 million in 2023

Taken together, these findings suggest GLP-1 RAs could broaden the therapeutic toolkit for HS, particularly for patients with concomitant obesity, and potentially even for those without, via anti-inflammatory effects

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