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Risk ratios (RR) for total death estimates according to direct (DPP-4 inhibitors, GLP-1RA and SGLT-2 inhibitors against placebo) and indirect (DPP-4 inhibitors vs GLP-1RA or SGLT-2 inhibitors, and GLP-1RA vs SGLT-2 inhibitors) comparisons

nevertheless, their most pronounced effect in obesity is appetite reduction through central nervous system (CNS) mechanisms, mainly within the hypothalamus [35]

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