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Common Off-Label Weight Loss Medications Metformin Originally used for type 2 diabetes and insulin resistance Helps improve insulin sensitivity and reduce abdominal fat Can reduce food intake Especially useful for patients with prediabetes, PCOS, or insulin resistance Topiramate (Topamax) An anti-seizure and migraine medication that can help reduce appetite and cravings Often used in combination with phentermine (as in Qsymia), but can be prescribed alone Bupropion (Wellbutrin) An antidepressant that may aid weight loss by affecting dopamine and norepinephrine Can reduce emotional eating Often paired with naltrexone (as in Contrave), but can also be used alone Naltrexone Originally used for addiction treatment (alcohol and opioid dependence) Helps reduce reward-driven eating and food cravings May be used alone or with bupropion (as in Contrave) Want to Know Whats Right for You
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