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Peptidomimetic compounds are designed to mimic the N-terminal dipeptide that is cleaved by DPP-IV

GLP-1RAs ameliorate ROS-induced or hyperglycemia-induced apoptosis through modulating IL-6 production and ER stress-induced by hyperhomocysteinemia, via stromal cell-derived factor (SDF)-1/C-X-C motif receptor 7 (CXCR7) -AMPK/p38-MAPK axis [113-115]

Measure against baseline weekly

For patients who frequently miss doses despite good intentions , it may be worth exploring whether there are underlying concerns about the medication, practical barriers to administration, or whether an alternative treatment approach might be more suitable