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The development of FoB in B cell-specific Gclc -deficient mice can be linked to the metabolic quiescence which characterizes wild-type FoB 38
Signs and symptoms can manifest as early as a few hours after birth, but may also only appear during adulthood, with a variation in clinical severity between patients even within the same family [20,21,22,23,24,25,26]
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Normal dermal fibroblasts were seeded into a 96-well cell culture plate and have been grown to confluence in high glucose media, supplemented with 10% fetal calf serum for around 3 days
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