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Longitudinal changes in diabetic retinopathy severity: learnings from PANORAMA
In contrast to exendin-4, which significantly lowered the blood glucose level from 15 to 120 min, exendin 2029 and the control (without pretreatment) did not change the glucose level during the experiment (Fig
3,5 In early T2DM managed with lifestyle alone, orforglipron lowered glycated hemoglobin A1c (HbA1c) by -1.24 to -1.48 percentage points over 40 weeks as compared to -0.41 with placebo, with no severe hypoglycemia reported and weight reduction ranging from 4.5% to 7.6%, 3 which led to mean HbA1c levels of 6.5-6.7%
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