Comparative effects of glucagon-like peptide-2 (GLP-2), growth hormone (GH), and keratinocyte growth factor (KGF) on markers of gut adaptation after massive small bowel resection in rats
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GLP-1 as well as its stable therapeutic analogs were shown to decrease the levels of inflammatory markers in peripheral tissues and brain cells
in retatrutide, this effect is thought to be offset by the concurrent GLP-1 and GIP receptor agonism, which promote insulin secretion