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When using dilute acetic acid (0.1% v/v) as a solvent, it can improve initial solubilization of certain peptide batches, but the solution pH should be adjusted to near-physiological range before administration to avoid tissue irritation at the injection site in animal models
doi:10.1073/pnas.1209474109 Attia, P
These signs indicate contamination or peptide degradation
This result indicated that dimeric copper peptides can accelerate the switch from the inflammatory to the proliferative phase by regulating the expression of inflammatory factors
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