What to supplement: Methylated B vitamins at moderate doses SAMe supplements under supervision Trimethylglycine (TMG/betaine) to support methylation Supplements that may help regardless of cause: For oxidative stress and glutathione support: NAC (N-acetylcysteine): provides cysteine directly Glycine: another glutathione building block Glutamine: supports gut health and glutathione Vitamin C: antioxidant support Alpha-lipoic acid: regenerates glutathione Selenium: supports glutathione peroxidase The careful approach to supplementation: Step 1: Identify the root cause Test B12, folate, and other relevant markers Assess diet and protein intake Consider genetic testing (MTHFR, CBS, COMT) Evaluate for oxidative stress, inflammation, or toxic burden Step 2: Address foundations first Optimise diet (see foods section) Reduce toxic exposures Support gut health Manage stress Improve sleep Step 3: Start low and go slow Begin with lowest effective doses Introduce one supplement at a time Monitor symptoms carefully Adjust based on response Step 4: Retest and reassess Recheck homocysteine after 2-3 months Monitor symptoms and overall health Adjust supplementation accordingly Work with a knowledgeable practitioner: Low homocysteine is complex and requires individualised treatment

A 2015 study published in the Journal of Pediatric Gastroenterology and Nutrition found that, for them, supplementation with glutathione three times per day with meals has been shown to decrease intestinal inflammation and improve growth in children
When certain types of oxygen molecules are allowed to travel freely in the body, they cause what is known as free radical damage
In Part 1 of this two-part series, we explain the importance of maintaining a healthy ratio of reduced-to-oxidized glutathione, present common illnesses that arise when imbalances are left untreated, explain the benefits of glutathione, and reveal the risks of having too much GSH