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99% purity by HPLC and mass spectrometry is essential and C18 fatty acid hydrolysis products restoring the unconjugated peptide backbone, Aib8-to-Ala8 epimerisation products restoring DPP-IV sensitivity, linker hydrolysis fragments, and aggregated fatty acid conjugate species would show substantially altered GLP-1R binding kinetics, half-life pharmacokinetics, and downstream signalling profiles confounding quantitative receptor pharmacology and comparative biology studies
Shukla AP, He D, Saunders KH, et al
ER stress: autophagy induction, inhibition and selection
There are also common side effects in all classes of GLP-1s
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