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Presented for research literature review only Arima J et al

3 Mammalian CHAC2: defining its role in glutathione homeostasis, cancer progression and stem cell fate In addition to CHAC1, which is found exclusively in higher eukaryotes, organisms from bacteria to mammals possess a CHAC2 enzyme that exhibits a highly similar glutathione-specific GCT activity (Kaur et al., 2017)

REIMAGINE 1 was a 40-week efficacy and safety phase 3 trial of CagriSema 2.4 mg/2.4 mg and 1 mg/1 mg once-weekly versus placebo in 189 adults with type 2 diabetes inadequately controlled on diet and exercise

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