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Large-scale epidemiological studies have confirmed that metformin users have a significantly lower risk of developing various malignancies, including bladder, lung, prostate, pancreatic, head and neck, esophageal, liver, and colorectal cancers, compared to non-users [10]

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doi: 10.1038/nrc1433 52 HirabayashiM.InoueM.SawadaN.SaitoE.AbeS

B cell-derived acetylcholine promotes liver regeneration by regulating Kupffer cell and hepatic CD8(+) T cell function