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Crucially, when they restarted the drug, they were unable to return to their previous lowest weight
Such therapy may, however, require several adjustments in dosage to attain an optimal dosage level and must be followed for life (Trovato 2020)
Thus, these data suggest that late-life targeting of IGF-1R signaling can recapitulate effects observed in genetic models of constitutive IGF-1R haploinsufficiency on lifespan
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