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Of note, however, in a 40 week Phase 3 study of overweight/obese individuals with type 2 diabetes, 36 mg of orforglipron taken orally once daily achieved reductions in HbA 1c of ~12 mmol/mol (1.07%) and in body weight of 5.9 kg (placebo subtracted) with an adverse event profile similar to that of the established GLP-1RA class [83]

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