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The evaluating clinician determines whether this option is appropriate based on individual health factors

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People with type 2 diabetes using GLP-1 receptor agonists, DPP-IV inhibitors or multiple therapies combining metformin, sulfonylureas, repaglinide, alpha-glucosidase inhibitors or thiazolidinediones from 2006 to 2018 were included

Perturbations of this axis, such as oral dysbiosis or compromised barrier function, have been increasingly implicated in the pathogenesis of diverse systemic diseases, which involve three key mechanistic pathways of how localized oral events could exert distant effects ( Table 1 )