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Specifically, inhibiting or depleting spinal microglia abolished the anti-allodynic effects of morroniside, while neutralizing IL-10 or -endorphin with targeted antibodies, or blocking the -opioid receptor, fully reversed morroniside-induced mechanical anti-allodynia [74]
Without demonstrated transdermal absorption, patches cannot be considered therapeutically equivalent to oral products
Thus, in the present study, we utilized paraffin-embedded pancreas sections from humans with CF or CFRD and age-matched non-CF/non-diabetic controls to quantify immunoreactivity of GLP-1 and GLP-1R via immunohistochemistry
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