![oral vs subq semaglutide vs. Injectable Semaglutide: Rybelsus, Ozempic & Wegovy Compared PDF] Effect of Oral Semaglutide](https://cdn.prod.website-files.com/60e33881a9643382c407b823/682da927e7ba1eb681747ec4_iStock-2173891474.jpeg)
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What we have is a plausible biological hypothesis (collagen peptide supplementation provides the amino acid substrates that bone matrix formation depends on, which may be relevant when those substrates are being depleted by rapid weight loss) supported by a strong positive RCT in a related population - and no direct evidence yet in the GLP-1 therapy population specifically
![oral vs subq semaglutide vs. Injectable Semaglutide: Rybelsus, Ozempic & Wegovy Compared PDF] Effect of Oral Semaglutide](https://figures.semanticscholar.org/e75b38795383820849921d05e6def18a1447e740/3-Figure1-1.png)
That puts him more in that second bucket of elite amateur, and probably needs to be held to a higher standard
![oral vs subq semaglutide vs. Injectable Semaglutide: Rybelsus, Ozempic & Wegovy Compared PDF] Effect of Oral Semaglutide](https://media.springernature.com/m685/springer-static/image/art%3A10.1007%2Fs40262-021-01025-x/MediaObjects/40262_2021_1025_Fig1_HTML.png)
Is it safe during pregnancy or breastfeeding
![oral vs subq semaglutide vs. Injectable Semaglutide: Rybelsus, Ozempic & Wegovy Compared PDF] Effect of Oral Semaglutide](https://www.mdpi.com/ijms/ijms-27-04694/article_deploy/html/images/ijms-27-04694-g003.png)
Take care not to overdo total fat
![oral vs subq semaglutide vs. Injectable Semaglutide: Rybelsus, Ozempic & Wegovy Compared PDF] Effect of Oral Semaglutide](https://www.frontiersin.org/files/Articles/645507/xml-images/fendo-12-645507-g001.webp)
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