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A deficiency of NAD+ may disrupt the circadian rhythm and result in effects such as daytime sleepiness, restless sleep, hormonal imbalances, and mood alterations, among others
More specifically, this may be observed with respect to certain genes, including Egr, Nos, Srf, Vegr, Akt1, Plc , and Kras genes (Vukojevic et al., 2018), all of which are responsible for the synthesis of factors necessary for a diverse set of processes
Active pharmaceutical ingredients such as anastrozole (an aromatase inhibitor) or clomiphene citrate (a selective estrogen receptor modulator (SERM)) are sometimes used in male patients to manage secondary hypogonadism while preserving fertility
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