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Proteins highly engaged by SCLA compounds were less labelled by subsequent treatment with an alkyne-modified probe, thereby showing a reduced signal following click chemistry, streptavidin pulldown and quantitative label-free MS (Fig
A widely used research tool for studying IGF-1 receptor (IGF-1R) signal transduction including PI3K/Akt pathway activation, MAPK/ERK phosphorylation cascades, and downstream transcription factor engagement in IGF-1R-expressing cell lines
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Rapamycin promotes endoMT during stress-induced premature senescence through the activation of autophagy [204]
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