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Tirzepatide is a 39-amino-acid synthetic peptide that simultaneously engages two incretin receptors: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor
Whether GLP-1R is expressed in endothelial cells remains controversial 28,33,34,35
Isoenzymes and activation [edit] The phospholipase C family consists of 13 isoenzymes split between six subfamilies, PLC- (1,3 & 4), -(1-4), -(1,2), -, -, and the recently discovered -(1,2) isoform
No such signal has been reported in available animal data, but research-grade caution is warranted
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