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Schedule prompt medical evaluation for: Progressive shortness of breath developing over days to weeks Breathing difficulty that worsens with lying flat (orthopnea) Nocturnal awakening due to breathlessness New or worsening leg swelling accompanied by dyspnea Persistent cough with breathing difficulty Exercise intolerance significantly worse than baseline Patients should not discontinue tirzepatide without medical guidance (except in cases of suspected severe allergic reaction), but they should communicate any respiratory symptoms to their healthcare provider promptly
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