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L-carnitine acts as a recipient of an acetyl group in a reaction that releases CoA for use in the Krebs cycle that generates energy (ATP) in the mitochondria
Therefore, dose adjustment is necessary in preclinical animal models
In patients with cirrhosis, the main risk factors for developing overt HE include MHE, sarcopenia, hyponatremia, epilepsy, type 2 diabetes, elevated creatinine, elevated bilirubin, and hypoalbuminemia.1 Because overt HE is a manifestation of decompensated liver failure, it has a negative impact on survival
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