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along with the DBD, contains a ligand dependent nuclear localization signal [62] E ) Ligand binding domain (LBD) containing activation function 2 (AF-2), responsible for agonist induced activity (activity in the presence of bound agonist) AF-2 binds either the N-terminal FXXFL motif intramolecularly or coactivator proteins (containing the LXXLL or preferably FXXFL motifs) [58] A ligand dependent nuclear export signal [63] F ) C-terminal domain Splice variants [edit] AR-V7 is an androgen receptor splice variant that can be detected in circulating tumor cells of metastatic prostate cancer patients [64] [65] and is predictive of resistance to some drugs (caused by missing Ligand-binding domain in this splice variant)

Never drink on an empty stomach Stay hydrated (water is your friend!) Check your medication timing Choose Your Drinks Wisely: Dry wine is usually a good choice due to less sugar Light beer works well as there is lower alcohol content Spirits with zero-calorie mixers will have less sugar Skip the sugary cocktails Listen to Your Body: Feeling extra queasy

Fungal infections are seen in different forms such as mild, superficial conditions, such as athletes foot or ringworm and serious infections that can even affect the internal organs