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Most melanotic macules are congenital, affect Caucasian individuals, may be single or multiple, have a diameter varying between 0.3cm and 3cm, tend to grow in proportion to the body growth, and are unrelated to any systemic condition.2,4 Their clinical features are not yet well-defined.1,2 The etiology of the disease still remains uncertain, but it is suggested that congenital cases may represent melanocyte hamartomas.2 Histology of the described cases of lingual melanotic macule reveals increased melanin in the basal cell layer, some pigment-laden macrophages in the dermis, normal number of melanocytes with no or a slight increase of melanin in their interior and variable degrees of hyperkeratosis.2 There are no nests of melanocytes, atypia, or alterations in the lingual tissue, and, in some cases, slight elongation of the epithelial ridges has been described.2 Also, according to Dohil et al., no similar histopathological alteration was identified in the non-affected lingual tissue.2 Our patient is an adult woman, which is uncommon when compared to other cases described

But the existing data, combined with what we know about GLP-1 receptor pharmacology, allows for some reasonable projections about what to expect over extended treatment periods

If youre not eating protein, your body takes it from your muscles

When planning your semaglutide diet, its important to include strategies for good sleep hygiene, such as avoiding screens before bedtime, minimizing caffeine intake throughout the day, keeping the bedroom cool and dark at night time, and also establishing a regular pattern by going to bed around the same time every night