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SARS-CoV-2 may activate TLR4 in the heart and lungs causing aberrant TLR4 signaling favoring the proinflammatory MyD88-dependent (canonical) pathway instead of the alternative TRIF/TRAM-dependent anti-inflammatory and interferon pathway (Aboudounya and Heads, 2021)
Other environmental triggers include: Heavy metals Pesticides and herbicides Air pollution Chemicals in cleaning products, personal care items, and building materials 4
Rice WRKY45 plays a crucial role in benzothiadiazole-inducible blast resistance
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