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Therefore, clinical testing in controlled populations is ultimately required to assess whether this preclinical efficacy is also observed in patients with CRC, both first-line in high-risk patients with high oxidative metabolic signalling (Fig
The test is usually terminated once the patient experiences a 20% decrease in breathing ability, or a maximum test dose of methacholine is achieved (American Lung Association - Methacholine Challenge Test)
It is crucial to consume the medication as prescribed and not to exceed the recommended dosage
Sartorelli & David G
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