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4-HNE is involved in PD pathology by covalently modifying -syn to promote its aggregation, disrupting the ubiquitin-proteasome system, and interfering with dopamine receptor function, and has been found to alter dopamine transport, contributing to dopamine loss (82, 86, 88)

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Australian summer transit above 40 C is less damaging to a small complex than to a large peptide, but prompt collection and refrigeration remains sensible