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Compensatory metabolic and endocrine processes do not totally counteract the weight loss effect
Exendin-4 is a 39-amino acid long peptide analog that shares a 53% sequence homology with human GLP-1 (Parkes, 2001)
Oral administration of these conjugates significantly improved glucose-lowering effects compared to native GLP-1, with DBP-GLP-1 showing superior efficacy likely attributed to enhanced intestinal absorption
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