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Its one of the cleanest GH-releasing peptides available, stimulating GH release without significantly affecting cortisol or prolactin levels

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A SURMOUNT-1 post-hoc analysis of 2,542 women, published in Obesity in 2025, found perimenopausal women on tirzepatide lost 23% of body weight against 3% on placebo, almost identical to the premenopausal result

Stress, illness, and hormonal changes are known triggers for reactivation, highlighting the need for individuals to manage their overall health and well-being to potentially reduce the frequency of outbreaks