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To put this in perspective: if you weigh 200 pounds, tirzepatide helped people lose an average of 50.3 pounds, versus 33.1 pounds with semaglutide

Warning: This product should not be taken by those with epilepsy or seizure disorders

The most common side effects of all five FDA-approved drugs include: Nausea Vomiting Diarrhea or constipation Stomach pain Other side effects that may occur include: Indigestion Gas/burping Bloating Tiredness Low blood sugar Decreased appetite Hair loss Injection site reactions (not applicable to Rybelsus, which is taken by mouth) Symptoms of a serious allergic reaction, such as hives, trouble breathing, or swelling of the face, lips, tongue, or throat, require emergency medical help