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The egg-PC diet lowered the frequency of CD3 + T cells with no significant differences in helper (CD3 + CD4 + ) and cytotoxic (CD3 + CD8 + ) T cells as well as activated T cells (CD3 + CD25 + ), reducing as well the production of IL-2 and TNF- 125) ( Figure 3 )
Competitor Eli Lilly's tirzepatide shows superior weight loss effects in some studies
Similar results were reported in the study of Chen et al., where high TMAO levels increased the expression of tumor necrosis factor- (TNF-) and interleukin-6 (IL-6), but inhibited the expression of anti-inflammatory cytokine interleukin-10 (IL-10), thereby accelerating cellular inflammation in obese mice treated with a Western diet (73)
The Phase 3 TRIUMPH-4 trial (NCT05869903) enrolled adults with obesity and knee osteoarthritis
