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RJVA-001 takes a different path: a potential one-time, pancreas-targeted gene therapy designed to enable the body to produce GLP-1 in response to meals: physiology, not pharmacology. Based in Burlington, Massachusetts, Fractyl Health develops novel approaches to treating obesity and type 2 diabetes
The studys results provide insights into some known and previously unrecognized benefits and risks of GLP-1RA that may be useful to inform clinical care and guide research agendas. Potential Downsides to GLP-1s Al-Aly emphasizes that his study also highlighted potential downsides to the medications, including an increased risk of gastrointestinal problems such as nausea, vomiting, diarrhea, and in rare cases paralysis of the stomach
This communication occurs through the vagus nerve, immune system signaling, hormones, and microbial metabolites
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