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Subsequently, superoxide rapidly reacts with nitric oxide (NO) to generate peroxynitrite, reducing NO bioavailability (Figure 1 summarizes how hyperglycemia increases platelet ROS generation, amplifying signaling and promoting a procoagulant phenotype

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AOD-9604 typically arrives as lyophilized (freeze-dried) powder in sealed vials requiring reconstitution with bacteriostatic water before injection