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Although the precise mechanisms of IL-6-associated IR is not well characterized, human adipocytes from IR individuals were shown to exhibit significantly higher IL-6 expression levels [45]
| 1st Phorm
FengYGaoMXuXLiuHLuKSongZet al
More direct MERC-directed screening has also yielded compound 24, first identified in HCT116 cells as a MERC enhancer, and subsequently shown to restore defective cholesterol trafficking, increased MERCs, enhanced LD formation and restoration of mitochondrial cristae architecture in an amyotrophic lateral sclerosis patient-derived cell model (163)
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