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55 Furthermore, GLP-1RAs promote beta cell proliferation and inhibit apoptosis
Thyroid C-cell tumors (rodent signal) - GLP-1 RAs carry a boxed warning regarding an increased risk of thyroid C-cell tumors in rodents
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Early clinical studies with Melanotan II unexpectedly identified potent pro-sexual and pro-erectile effects in male volunteers effects mediated centrally through the melanocortin system rather than through peripheral vascular mechanisms which prompted the development of PT-141 as a purpose-designed, more selective CNS melanocortin agonist optimised for sexual behaviour research and clinical application
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