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Chronic pain, autoimmune diseases, anxiety and depression are more prevalent in women especially during reproductive age probably due to increased negative life events, sensitivity of adrenal cortex and the influence of steroid hormones such as estradiol as well as progesterone[30-32]
PMID 25188246
Brit J Clin Pharmacol
Anyway, the fact is that some people manage perfectly well on a 1mg injection every three months but others, and the vast majority of the PA Society do not, and they feel a return of their symptoms, or their family and friends notice a return of their symptoms long before their next injection is due
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