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Complete inhibition of v-ATPase-dependent lysosomal acidification is associated with cellular iron deficiency and subsequent mitochondrial dysfunction affecting mitochondrial-iron-sulfur cluster integration into OXPHOS complexes 37
This bidirectional relationship is clinically evident in the early elevation of OS biomarkers (e.g., urinary 8-OHdG, serum F2-isoprostanes) preceding overt DM and their correlation with disease severity and complications (e.g., retinopathy, nephropathy)
Collagen is the bodys most abundant protein, giving structure to bones, cartilage, tendons, ligaments, muscles and skin
They were testing the theory that mitochondrial decline is caused by free radical damage (see panel opposite)
