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Lipka et al
FDA has approved metformin for managing Type 2 diabetes, and healthcare providers frequently utilize it off-label for a variety of other conditions, including addressing weight gain associated with certain medications, managing gestational diabetes, preventing the onset of Type 2 diabetes in high-risk individuals, and treating PCOS
It is tempting to speculate that this apparent loss of benefit in patients with more advanced HF may be the result of increases in HR caused by activation of sinoatrial node (SAN) GLP-1Rs (64, 65), which could be mitigated with an agent such as GLP-1(2836) that retains cardiac and vascular protection of GLP-1, without activating the GLP-1R
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