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In spinal cord tissues from patients with ALS, the expression of arachidonate 5-Lipoxygenase (ALOX5) and complement component 3 (C3) was markedly upregulated, accompanied by reduced GSH levels, elevated iron concentrations, and enhanced lipid peroxidation

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Furthermore, sorafenib-resistant HCC cells exhibit enhanced serine synthesis, which promotes GSH production and augments the antioxidant system [123]